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Can testosterone impact mood and mental health?

Testosterone has a notable impact on mood and mental health. Low testosterone levels have been associated with symptoms such as irritability, fatigue, and mood disturbances, which can contribute to feelings of depression and anxiety.

Testosterone's influence on mood regulation is complex, involving interactions with neurotransmitter systems like serotonin and dopamine. Moreover, testosterone may affect brain structure and function, particularly in regions linked to emotional processing.


  1. Almeida, O. P., Waterreus, A., Spry, N., Flicker, L., Martins, R. N., Gulumian, M., & Lautenschlager, N. T. (2008). One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology, 33(6), 782-791. doi: 10.1016/j.psyneuen.2008.02.011

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